Curriculum vitae

Name Surname Rokas Mikšiūnas
Education
Institution Qualification, academic degree, academic title Year
Vilnius University Bachelor's Degree in Genetics, higher education 2014
Vilnius University Master's Degree in Genetics, higher Education 2016
State Research Institute Centre for Innovative Medicine Doctoral degree in biology 2021
Work experience
Employer Occupation Period
State Research Institute Centre for Innovative Medicine Scientist 2017-2024
VILNIUS TECH Lecturer 2021-2023
Scientific works, works of artistic creation
Period Work title and description
2013-2014 Bachelor's Degree thesis: "Characterization of Uracil-DNA glycosylases from psychrophilic microorganisms" (Thermo Fisher Scientific Baltics, Vilnius).
2014-2016 Master's Degree thesis: "Development of restriction endonucleases directed in vitro evolution scheme" (Thermo Fisher Scientific Baltics, Vilnius).
2016-2021 PhD Degree thesis: "REGENERATION POTENTIAL OF HUMAN DILATED MYOCARDIUM-DERIVED MESENCHYMAL STROMAL CELLS IN VITRO: THE IMPACT OF HISTONE DEACETYLASE INHIBITORS AND BIOMATRICES" (State Research Institute Centre of Innovative Medicine Centre for Innovative medicine, Vilnius)
Main publications, monographs, art works, patents
Field of Science Publications Year
Biology R. Miksiunas, A. Mobasheri, D. Bironaite (2020). Homeobox Genes and Homeodomain Proteins: New Insights into Cardiac Development, Degeneration and Regeneration. Adv Exp Med Biol. 1212:155-178. doi: 10.1007/5584_2019_349 2019
Electrochemistry J. Petroniene, I. Morkvenaite-Vilkonciene, R. Miksiunas, D. Bironaite, A. Ramanaviciene, L. Mikoliunaite, A. Kisieliute, K. Rucinskas, V. Janusauskas, I. Plikusiene, S. Labeit, A. Ramanavicius (2020). Evaluation of Redox Activity of Human Myocardium-derived Mesenchymal Stem Cells by Scanning Electrochemical Microscopy. Electroanalysis. 32(6), 1337–1345. doi.org/10.1002/elan.201900723 2020
Biology R. Miksiunas, K. Rucinskas, V. Janusauskas, S. Labeit, D. Bironaite (2020). Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells. Int J Mol. 21(14):4845. doi: 10.3390/ijms21144845. 2020
Biology I. Kulvinskiene, R. Aldonyte, R. Miksiunas, A. Mobasheri, D.Bironaite (2020). Biomatrices for Heart Regeneration and Cardiac Tissue Modelling In Vitro. Adv Exp Med Biol. 1298:43-77. doi: 10.1007/5584. 2020
Electrochemistry J. Petroniene, I. Morkvenaite-Vilkonciene, R. Miksiunas, D. Bironaite, A. Ramanaviciene, K. Rucinskas, V. Janusauskas, A. Ramanavicius (2020). Scanning electrochemical microscopy for the investigation of redox potential of human myocardium-derived mesenchymal stem cells grown at 2D and 3D conditions. Electrochimica Acta, 360. doi.org/10.1016/j.electacta.2020.136956 2020
Biology Mikšiūnas R, Labeit S, Bironaitė D. The Effect of Heat Shock on Myogenic Differentiation of Human Skeletal-Muscle-Derived Mesenchymal Stem/Stromal Cells. Cells. 2022 Oct 13;11(20):3209. doi: 10.3390/cells11203209. PMID: 36291076; PMCID: PMC9600296. 2022
Biology Miksiunas R, Aldonyte R, Vailionyte A, Jelinskas T, Eimont R, Stankeviciene G, Cepla V, Valiokas R, Rucinskas K, Janusauskas V, Labeit S, Bironaite D. Cardiomyogenic Differentiation Potential of Human Dilated Myocardium-Derived Mesenchymal Stem/Stromal Cells: The Impact of HDAC Inhibitor SAHA and Biomimetic Matrices. Int J Mol Sci. 2021 Nov 24;22(23):12702. doi: 10.3390/ijms222312702. PMID: 34884505; PMCID: PMC8657551. 2022
Biology Uzieliene I, Bironaite D, Miksiunas R, Bagdonas E, Vaiciuleviciute R, Mobasheri A, Bernotiene E. The Effect of CaV1.2 Inhibitor Nifedipine on Chondrogenic Differentiation of Human Bone Marrow or Menstrual Blood-Derived Mesenchymal Stem Cells and Chondrocytes. Int J Mol Sci. 2023 Apr 4;24(7):6730. doi: 10.3390/ijms24076730. PMID: 37047701; PMCID: PMC10095444. 2023
Participation in conferences
Date Title of the conference and speech title
2019-09-11 Oral presentation. R.Miksiunas, G.Juskaite, D.Bironaite. The effect of heat shock on molecular mechanisms regulating regeneration of skeletal system. Europe Muscle Conference 2019, University of Kent, Canterbury, United Kingdom, 2019 September 7-11.
2020-01-25 Poster presentation: R. Miksiunas, I. Bruzauskaite , R. Aldonyte , K. Rucinskas, V. Janusauskas , S. Labeit , D. Bironaite. HDAC inhibitors promote energetic status of human myocardium-derived mesenchymal stem cells. Heart Failure Winter Meeting 2020, Les Diablerets, Maison des Congrès, Switzerland, 2020 January 23-25.
2021-03-30 Poster presentation. A. Aleksandraviciute, R. Miksiunas, K. Rucinskas, V. Janusauskas, D. Bironaite. REGENERATIVE PROPERTIES OF HUMAN DILATED ATRIUM-DERIVED MESENCHYMAL STEM/STROMAL CELLS. International Conference The COINS 2021, Vilnius, 2021 March 30.
2021-09-20 Poster presentation. R. Miksiunas, J.Buivydaviciute, R.Aldonyte, A.Vailionyte, T.Jelinskas, R.Eimont, G.Stankeviciene, V.Cepla, A.Ulcinas, R.Valiokas, K.Rucinskas, V.Janusauskas, S.Labeit, D.Bironaite. Effects of biomimetic substrates on dilated myocardium human myocardium-derived mesenchymal stromal cells cardiac differentiation in vitro. Virtual European Muscle Conference, September 20 - 22, 2021, Warsaw operated.R. Miksiunas, J.Buivydaviciute, R.Aldonyte, A.Vailionyte, T.Jelinskas, R.Eimont, G.Stankeviciene, V.Cepla, A.Ulcinas, R.Valiokas, K.Rucinskas, V.Janusauskas, S.Labeit, D.Bironaite. Effects of biomimetic substrates on dilated myocardium human myocardium-derived mesenchymal stromal cells cardiac differentiation in vitro. Virtual European Muscle Conference, September 20 - 22, 2021, Warsaw operated.
2022-09-22 Poster presentation. R.Miksiunas, K.Rucinskas, V.Janusauskas, S.Labeit, E.Bernotienė, D.Bironaite. Regenerative potential of cardiosphere-derived cells from human dilated myocardium. Europe Muscle Conference 2022, Institute of the Molecular Genetics, Prague, Lithuania, 2022 September 22-26.
Foreign languages
A1/2: beginner; B1/2: advanced user; C1/2: proficient user;
Speaking Understanding Writing
English C1 C1 C1
Teaching subjects
Level of studies Subject title
Master Degree Studies Tissue Engineering
Master Degree Studies Stem Cell Biology and Technology (with course work)
Improvement of qualification (internships, lasting more than two weeks, trainings, seminars, not less than 8
Institution Country Subject Period
KTU Lithuania 3rd PhD summer school 2018-2018
Participation in projects
Period Project description
2017-2020 Scientist group project: “Evaluation of human heart muscle cardioshere potential and mechanoptosis mechanisms in dilated myocadium mesenchymal stem cells”. S-MIP-17-13. 2017–2020 m.
2017-2021 EU fund grant No. 09.3.3-LMT-K-712-01-0157. “Mechanotransductive L-type Calcium Channels as a Therapeutic Target for Metabolic Modulation of Osteoarthritic Cartilage” 2018–2021
2021-2025 Horizon 2020 grant No. 953138. “ElectroMechanoActive Polymer-based Scaffolds for Heart-on-Chip (EMAPS)” 2021–2025