The dissertation was defended at the public meeting of the Dissertation Defence Council of the Scientific Field of Mechanical Engineering in the SRA-I Hall of Vilnius Gediminas Technical University at 9 a.m. on 5 July 2024.
The effects of osteoporosis on the human body have been extensively de-scribed in the scientific literature. The focus is on human health, while ani-mals are used only as laboratory subjects and receive little attention. There-fore, this dissertation focuses on the canine lumbar spine, its changes in the context of osteoporosis and biomechanics, and the studies that have been performed to determine the risk of fracture of the affected vertebrae. In the preparation of the dissertation, a finite element method was used to con-struct a numerical model of the canine lumbar spine. In addition, biomechanical, imaging and histopathological tests were performed, and an analysis of the data obtained was presented. The aim of the dissertation was achieved through four objectives. A digital model of the canine lumbar spine was constructed, and biomechanical calculations were subsequently performed using the model to assess the changes in biomechanical performance associated with osteoporosis. Micro-computed tomography (micro-CT) allowed the assessment of the structure and density of the canine lumbar vertebral bone tissue. The histomorphometric studies allowed for a more detailed analysis of the structure and density of the bone tissue, as well as the influence of the mechanical properties. A unique fracture risk score has been proposed to analyse the specific biological risk factors affecting canine bone tissue. The dissertation consists of an introduction, three chapters, general conclusions, a list of references, a list of publications and conference presentations, an abstract in English and four appendices. The introduction discusses the problem, the relevance, the objects of study, the aim and objectives of the dissertation, the novelty and the practical significance. The chapters provide a detailed description of the context of osteoporosis in medicine, veterinary medicine and biomechanics, present the study methodology, model development and the development of a risk score calculator, and analyse the activity of the dogs before and after castration. The third chapter presents the results which demonstrate that dogs can develop osteoporosis. These results are substantiated by the detection of large pores in the lumbar spine using micro-computed tomography and histomorphometry, as well as validation of the real and numerical models. Four scientific publications have been published on the topic of the dissertation, indexed in the Clarivate Analytics Web of Science database. The results of the research were presented at six scientific conferences in Lithuania and abroad. It is hoped that this thesis will stimulate further research in this field and lead to new considerations on the treatment of osteoporosis in dogs, with due attention being paid to the health research of these animals.
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